吕平江
姓名 吕平江
职称 教授
联络电话 03-5742762
实验室分机 03-575131#33489
联络地址 生科二馆306室
电子邮件 pclyu@mx.nthu.edu.tw
个人网站 http://biobug.life.nthu.edu.tw/
职衔 清华大学副校长
授课领域 结构生物、生物资讯、蛋白质工程
研究专长 蛋白质结构及生物资讯学(以下是最近几年的研究主题) * 脂质传送蛋白(Lipid Transfer Proteins (LTPs))的结构、折叠和功能性研究 * 葡聚醣之结合胜呔设计 * 胃幽门杆菌(Helicobacter Pylori)结构基因体计画 * 生物资讯在结构生物上的应用
年度 论文名称
2011 Cheng, C.S., Chen, W.T., Lee, L.H., Chen, Y.W., Chang, S.Y., Lyu, P.C. and Yin, H.S., Structural and functional comparison of cytokine interleukin-1 beta from chicken and human, Molecular Immunology, 48, 6-7, pp947-955, (SCI)
2011 Chang, C.W., Lyu, P.C. and Arita, M., Reconstructing phylogeny from metabolic substrate-product relationships, BMC Bioinformatics, 12, S1, (SCI)
2011 Yang, J.T., Chen, C.K., Hu, I.C. and Lyu, P.C, Design of a self-flapping microfluidic oscillator and diagnosis with fluorescence methods, Journal of Microelectromechanical Systems, 16, 4, pp826-835, (SCI)
2010 Peng, Y.H., Coumar, M.S., Leou, J.S., Wu, J.S., Shiao, H.Y., Lin, C.H., Lin, W.H., Lien, T.W., Chen, X., Hsu, J.T.A., Chao, Y.S., Huang, C.F., Lyu, P.C., Hsieh, H.P. and Wu, S.Y. , Structural Basis for the Improved Potency of Peroxisome Proliferator-Activated Receptor (PPAR) Agonists, Chemmedchem, 5, 10, pp1707-1716, (SCI)
2010 Wey, M.T., Lyu, P.C. and Kan, L.S. , Thermodynamic and Kinetic Studies of a Stable Imperfect DNA Triplex by Spectroscopic and Calorimetric Methods, Journal of the Chinese Chemical Society, 57, 3B, pp496-504, (SCI)
2010 Tseng, H.C., Lyu, P.C. and Lin, W.C., Nuclear localization of orphan receptor protein kinase (Ror1) is mediated through the juxtamembrane domain, BMC Cell Biology, 11, pp48-, (SCI)
2010 Pan, T.L., Hung, Y.C., Wang, P.W., Chen, S.T., Hsu, T.K., Sintupisut, N., Cheng, C.S. and Lyu, P.C., Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells, Proteomics, 10, 5, pp914-929, (SCI)
2010 Lee, T.S., Pan, C.C., Peng, C.C., Kou, Y.R., Chen, C.Y., Ching, L.C., Tsai, T.H., Chen, S.F., Lyu, P.C. and Shyue, S.K, Anti-Atherogenic Effect of Berberine on LXR alpha-ABCA1-Dependent Cholesterol Efflux in Macrophages, Journal of Cellular Biochemistry, 111, 1, pp104-110, (SCI)
2010 Huang, P.J., Liu, Y.C., Lee, C.C., Lin, W.C., Gan, R.R.C., Lyu, P.C.* and Tang, P. , DSAP: deep-sequencing small RNA analysis pipeline, Nucleic Acids Research, 38, S2, ppW385-W391, (SCI)
2010 Huang, H. L., Hsing, H.W., Lai, T.C., Chen, Y.W., Lee, T.R., Chan, H.T., Lyu, P.C., Wu, C.L., Lu, Y.C., Lin, S.T., Lin, C.W., Lai, C.H., Chang, H.T., Chou, H.C. and Chan, H.L., Trypsin-induced proteome alteration during cell subculture in mammalian cells, Journal of Biomedical Science, 17, pp36-, (SCI)
2010 Hsu, R.M., Tsai, M.H., Hsieh, Y.J., Lyu, P.C. and Yu, J.S, Identification of MYO18A as a Novel Interacting Partner of the PAK2/beta PIX/GIT1 Complex and Its Potential Function in Modulating Epithelial Cell Migration, Molecular Biology of the Cell, 21, 2, pp287-301, (SCI)
2010 Hsieh, Y.J., Yu, J.S. and Lyu, P.C., Characterization of Photodynamic Therapy Responses Elicited in A431 Cells Containing Intracellular Organelle-Localized Photofrin, Journal of Cellular Biochemistry , 111, 4, pp821-833, (SCI)
2010 Ho, M.R., Lou, Y.C., Wei, S.Y., Luo, S.C., Lin, W.C., Lyu, P.C. and Chen, C.P, Human RegIV Protein Adopts a Typical C-Type Lectin Fold but Binds Mannan with Two Calcium-Independent Sites, Journal of Molecular Biology , 402, 4, pp682-695, (SCI)
2010 Chu, C.H., Lo, W.C., Wang, H.W., Hsu, Y.C., Hwang, J.K., Lyu, P.C., Pai, T.W. and Tang, C.Y, Detection and Alignment of 3D Domain Swapping Proteins Using Angle-Distance Image-Based Secondary Structural Matching Techniques, PLOS One, 5, 10, (SCI)
2010 Chou, H.C., Chen, Y.W., Lee, T.R., Wu, F.S., Chan, H.T., Lyu, P.C., Timms, J.F. and Chan, H.L., Proteomics study of oxidative stress and Src kinase inhibition in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment, Free Radical Biology and Medicine, 49, 1, pp96-108, (SCI)
2010 Chen, J.C., Uang, B.J., Lyu, P.C., Chang, J.Y., Liu, K.J., Kuo, C.C., Hsieh, H.P., Wang, H.C., Cheng, C.S., Chang, Y.H., Chang, M.D.T., Chang, W.S.W. and Lin, C.C. , Design and Synthesis of alpha-Ketoamides as Cathepsin S Inhibitors with Potential Applications against Tumor Invasion and Angiogenesis, Journal of Medicinal Chemistry, 53, 11, pp4545-4549, (SCI)
2009 Yang, Y.F., Cheng, K.C., Tsai, P.H., Liu, C.C., Lee, T.R. and Lyu, P.C., Alanine substitutions of noncysteine residues in the cysteine-stabilized alpha beta motif, Protein Science , 18, 7, pp1498-1506, (SCI)
2009 Lo, W.C., Lee, C.Y., Lee, C.C. and Lyu, P.C., iSARST: an integrated SARST web server for rapid protein structural similarity searches, Nucleic Acids Research , 37, ppW545-W551, (SCI)
2009 Lo, W.C., Lee, C.C., Lee, C.Y. and Lyu, P.C., CPDB: a database of circular permutation in proteins, Nucleic Acids Research, 37, ppD328-D332, (SCI)
2009 Lo, A., Chiu, Y.Y., Rodland, E.A., Lyu, P.C., Sung, T.Y. and Hsu, W.L., Predicting helix-helix interactions from residue contacts in membrane proteins, Bioinformatics, 25, 8, pp996-1003, (SCI)
2009 Ku, T.H., Lu, P.Y., Chan, C.H., Wang, T.S., Lai, S.Z., Lyu, P.C. and Hsiao, N.W, Predicting melting temperature directly from protein sequences, Computational Biology and Chemistry , 33, 6, pp445-450, (SCI)
2009 Chiang, Y.K., Kuo, C.C., Wu, Y.S., Chen, C.T., Coumar, M.S., Wu, J.S., Hsieh, H.P., Chang, C.Y., Jseng, H.Y., Wu, M.H., Leou, J.S., Song, J.S., Chang, J.Y., Lyu, P.C., Chao, Y.S. and Wu, S.Y, Generation of Ligand-Based Pharmacophore Model and Virtual Screening for Identification of Novel Tubulin Inhibitors with Potent Anticancer Activity, Journal of Medicinal Chemistry , 52, 14, pp4221-4233, (SCI)
2009 Chen, T., Lee, T.R., Liang, W.G., Chang, W.S.W. and Lyu, P.C., Identification of trypsin-inhibitory site and structure determination of human SPINK2 serine proteinase inhibitor, Proteins-Structure Function and Bioinformatics, 77, 1, pp209-219, (SCI)
2008 Yang, Y.F., Chou, M.Y., Fan, C.Y., Chen, S.F., Lyu, P.C., Liu, C.C. and Tseng, T.L, The possible interaction of CDA14 and protein elongation factor 1 alpha, Biochimica Et Biophysica Acta-Proteins and Proteomics, 1784, 2, pp312-318, (SCI)
2008 Lo, W.C. and Lyu, P.C., CPSARST: an efficient circular permutation search tool applied to the detection of novel protein structural relationships, Genome Biology, 9, 1, ppR11-, (SCI)
2008 Lo, A., Chiu, H.S., Sung, T.Y., Lyu, P.C. and Hsu, W.L, Enhanced membrane protein topology prediction using a hierarchical classification method and a new scoring function, Journal of Proteome Research, 7, 2, pp487-496, (SCI)
2008 Liao, C.J., Chin, K.H., Lin, C.H., Tsai, P.S.F., Lyu, P.C., Young, C.C., Wang, A.H.J. and Chou, S.H., Crystal structure of DFA0005 complexed with alpha-ketoglutarate: A novel member of the ICL/PEPM superfamily from alkali-tolerant Deinococcus ficus, Proteins-Structure Function and Bioinformatics , 73, 2, pp362-371, (SCI)
2008 Lai, Y.T., Cheng, C.S., Liu, Y.N., Liu, Y.J. and Lyu, P.C., Effects of ligand binding on the dynamics of rice nonspecific lipid transfer protein 1: A model from molecular simulations, Proteins-Structure Function and Bioinformatics, 72, 4, pp1189-1198, (SCI)
2008 Hsiao, C.J., Li, T.K., Chan, Y.L., Hsin, L.W., Liao, C.H., Lee, C.H., Lyu, P.C. and Guh, J.H., WRC-213, an L-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: Identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers, Biochemical Pharmacology, 75, 4, pp847-856, (SCI)
2008 Hsiao, C.J., Ho, Y.F., Hsu, J., Chang, W.L., Chen, Y.C., Shen, Y.C., Lyu, P.C. and Guh, J.H., Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress, Naunyn-Schmiedebergs Archives of Pharmacology, 378, 6, pp599-608, (SCI)
2008 Cheng, C.S., Chen, M.N., Lai, Y.T., Chen, T., Lin, K.F., Liu, Y.J. and Lyu, P.C, Mutagenesis study of rice nonspecific lipid transfer protein 2 reveals residues that contribute to structure and ligand binding, Proteins-Structure Function and Bioinformatics, 70, 3, pp695-706, (SCI)
2007 Lin, S.C., Chueh, S.C., Hsiao, C.J., Li, T.K., Chen, T.H., Liao, C.H., Lyu, P.C., and Guh, J.H, Prazosin displays anticancer activity against human prostate cancers: Targeting DNA and cell cycle, Neoplasia, 9, 10, pp830-839, (SCI)
2007 Lo, W.C., Huang, P.J., Chang, C.H. and Lyu, P.C, Protein structural similarity search by Ramachandran codes, BMC Bioinformatics, 8, pp307-, (SCI)
2007 Yang, J.T., Huang, K.J., Tung, K.Y., Hu, I.C. and Lyu, P.C, A chaotic micromixer modulated by constructive vortex agitation, Journal of Micromechanics and Microengineering, 17, 10, pp2084-2092, (SCI)
2007 Lin, K.F., Lee, T.R., Tsai, P.H., Hsu, M.P., Chen, C.S. and Lyu, P.C, Structure-based protein engineering for alpha-amylase inhibitory activity of plant defensin, Proteins-Structure Function and Bioinformatics, 68, 2, pp530-540, (SCI)
2007 Liu, Y.N., Lai, Y.T., Chou, W.I., Chang, M.D.T. and Lyu, P.C, Solution structure of family 21 carbohydrate-binding module from Rhizopus oryzae glucoamylase, Biochemical Journal, 403, pp21-30, (SCI)
2007 Wang, L.L., Yang, J.T. and Lyu, P.C, An overlapping crisscross micromixer, Chemical Engineering Science, 62, 3, pp711-720, (SCI)
2007 Ruan, S.K., Chin, K.H., Shr, H.L., Lyu, P.C., Wang, A.H.J. and Chou, S.H, Preliminary X-ray analysis of XC5848, a hypothetical ORFan protein with an Sm-like motif from Xanthomonas campestris, Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 63, pp30-33, (SCI)
2007 Yang, J.T., Chen, C.K., Hu, I.C. and Lyu, P.C, Design of a self-flapping microfluidic oscillator and diagnosis with fluorescence methods, Journal of Microelectromechanical Systems, 16, 4, pp826-835, (SCI)
2006 Lin, C.W., Lin, K.H., Lyu, P.C., and Chen, W.J, apanese encephalitis virus NS2B-NS3 protease binding to phage-displayed human brain proteins with the domain of trypsin inhibitor and basic region leucine zipper, Virus Research, 116, 1-2, pp106-113, (SCI)
2006 Mahindroo, N., Wang, C.C., Liao, C.C., Huang, C.F., Lu, I.L., Lien, T.W., Peng, Y.H., Huang, W.J., Lin, Y.T., Hsu, M.C., Lyu, P.C., Chao, Y.S., Wu, S.Y., and Hsieh, H.P, Indol-1-yl acetic acids as peroxisome proliferator-activated receptor agonists:Design, synthesis, structural biology, and molecular docking studies, Journal of Medicinal Chemistry, 49, 3, pp1212-1216, (SCI)
2006 Ho, M.R., Lou, Y.C., Lin, W.C., Lyu, P.C., Huang, W.N. and Chen, C, Human pancreatitis-associated protein forms fibrillar aggregates with a native-like conformation, Journal of Biological Chemistry , 281, 44, pp33566-33576, (SCI)
2006 Mahindroo, N., Peng, Y.H., Lin, C.H., Tan, U.K., Prakash, E., Lien, T.W., Lu, I.L., Lee, H.J., Hsu, J.T.A., Chen, X., Liao, C.C., Lyu, P.C., Chao, Y.S., Wu, S.Y. and Hsieh, H.P, Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists, Journal of Medicinal Chemistry, 49, 21, pp6421-6424, (SCI)
2006 Hu, I.C., Lee, T.R., Lin, H.F., Chiueh, C.C., and Lyu, P.C, Biosynthesis of fluorescent allophycocyanin alpha-subunits by autocatalytic bilin attachment, Biochemistry , 45, 23, pp7092-7099, (SCI)
2006 Liu, Y.J., Cheng, C.S., Lai, S.M., Hsu, M.P., Chen, C.S., and Lyu, P.C, Solution structure of the plant defensin VrD1 from mung bean and its possible role in insecticidal activity against bruchids, Proteins-Structure Function and Bioinformatics, 63, 4, pp777-786, (SCI)
2006 Tsai, J.Y., Chen, B.T., Cheng, H.C., Chen, H.C., Hsaio, N.W., Lyu, P.C., and Sun, Y.J, Crystal structure of HP02429, a hypothetical protein from Helicobaccter pylori wrath a novel fold, Proteins-Structure Function and Bioinformatics, 62, 4, pp1138-1143, (SCI)
2006 Lo, W.T., Chin, K.H., Shr, H.L., Gao, F.P., Lyu, P.C., Wang, A.H.J. and Chou, S.H, Crystallization and preliminary X-ray analysis of XC1015, a histidine triad-like protein from Xanthomonas campestris, Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 62, pp1263-1265, (SCI)
2006 Lin, C.H., Chin, K.H., Gao, F.P., Lyu, P.C., Shr, H.L., Wang, A.H.J. and Chou, S.H, Cloning, crystallization and preliminary X-ray studies of XC2981 from Xanthomonas campestris, a putative CutA1 protein involved in copper-ion homeostasis, Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 62, pp1113-1115, (SCI)
2006 Tsai, Y.D., Chin, K.H., Shr, H.L., Gao, F.P., Lyu, P.C., Wang, A.H.J. and Chou, S.H., Cloning, crystallization and preliminary X-ray study of XC1258, a CN-hydrolase superfamily protein from Xanthomonas campestris, Acta Crystallographica Section F-Structural Biology and Crystallization Communications , 62, pp999-1002, (SCI)
2006 Chio, K.C., Chin, K.H., Gao, F.P., Lyu, P.C., Shr, H.L., Wang, A.H.J. and Chou, S.H, The cloning, crystallization and preliminary X-ray analysis of XC2113, a YaeQ protein from Xanthomonas campestris, Acta Crystallographica Section F-Structural Biology and Crystallization Communications, 62, pp1046-1048, (SCI)
国家 学校名称 系所 学位 期间
美国 美国纽约大学 化学系 博士 1987.09 ~ 1991.05
美国 纽泽西理工学院 化学 硕士 1985.09 ~ 1987.05
台湾 东海大学 化学 学士 1978.09 ~ 1982.06
服务机关名称 单位 职务 期间
国立清华大学 医学科学系 教授 2011.08 ~ 2012.07
国立清华大学 生命科学系 教授 2002.02 ~ 2011.08
国立清华大学 生命科学系 副教授 1994.08 ~ 2002.02
美国加州大学柏克莱分校 化学系 博士后研究员 1991.12 ~ 1994.06