庄永仁
姓名 庄永仁
职称 教授
联络电话 03-5742764
实验室分机 03-5715131#33451
联络地址 生科二馆410室
电子邮件 yjchuang@life.nthu.edu.tw
个人网站 http://myjchuang.wixsite.com/yjc-lab
职衔 清华特聘教授
授课领域 心血管生物学、癌症药物机制、功能基因体学、分子调控
研究专长 我们实验室以[心血管生物学]和[癌症药物机制]等相关疾病之转译研究为基础。 目前研究课题如下: 1. 心脏与其他重要器官创伤后之修复与再生 2. 精准癌症治疗-复合药物及疗法的选择 3. 硼中子捕获治疗(BNCT)作用机制 4. 以斑马鱼为人类疾病研究与药物筛检平台
年度 论文名称
2020 Shih M, Kuo CT, Lin MH, Chuang YJ, Chen H, Yew TR,, A 3D-CNT Micro-electrode Array for Zebrafish ECG Study including Directionality Measurement and Drug Test, Biocybernetics and Biomedical Engineering, (SCI)
2020 Liu LY, Lai ZY, Lin MH, Shih Y, Chuang YJ*, Bioinformatics analysis of hereditary disease gene set to identify key modulators of myocardial remodeling during heart regeneration in zebrafish, EPiC Series in Computing, 70, pp226-237, (Others)
2020 Liu WT, Wu CY, Lu MJ, Chuang YJ, Tsai EM, Leu S, Lin IL, Ko CJ, Chiu CC, Chang WT. , Phenoxyphenol Compound 4-HPPP Selectively Induces Antiproliferation Effects and Apoptosis in Human Lung Cancer Cells through Aneupolyploidization and ATR DNA Repair Signaling, Oxidative Medicine and Cellular Longevity, 2020, (SCI)
2019 Chen KH, Lai ZY, Li DY, Lin YC, Chou FI, Chuang YJ, Analysis of DNA Damage Responses after Boric Acid-mediated Boron Neutron Capture Therapy in Hepatocellular Carcinoma, Anticancer Research, 39, 12, pp6661-6671, (SCI)
2019 Hung YH, Lin YC, Lin YT, Shih GW, Liao JW, Chen KS, Liu HM, Chen YW, Chuang YJ, Yang CM, Peir JJ, Yang CH, Chou FI., Therapeutic Efficacy and Radiobiological Effects of Boric Acid-mediated BNCT in a VX2 Multifocal Liver Tumor-bearing Rabbit Model, Anticancer Research, 39, 10, pp5945-5504, (SCI)
2019 Lin YT, Liang SM, Wu YJ, Wu YJ, Lu YJ, Jan YJ, Ko BS, Chuang YJ, Shyue SK, Kuo CC, Liou JY*, Cordycepin suppresses endothelial cell proliferation, migration, angiogenesis and tumor growth by regulating focal adhesion kinase and p53, Cancers, (SCI)
2018 Chao Shen⁠, Yixi Zhou⁠,Jinpeng Ruan, Yung-Jen Chuang⁠c, Chonggang Wang⁠, Zhenghong Zuo⁠, Generation of a Tg(cyp1a-12DRE: EGFP) transgenic zebrafish line as a rapid in vivo model for detecting dioxin-like compounds, Aquatic Toxicology, 205, pp174-181, (SCI)
2018 Min-Hsuan Lin, Huang-Cheng Chou, Yu-Fu Chen, Wangta Liu, Chi-Chun Lee, Lawrence Yu-Min Liu, and Yung-Jen Chuang, Development of a rapid and economic in vivo electrocardiogram platform for cardiovascular drug assay and electrophysiology research in adult zebrafish, Scientific Reports, 8, 1, pp15986-, (SCI)
2018 Chang Z, Chen PY, Chuang YJ, Akhtar R., Zebrafish as a model to study bone maturation: nanoscale structural and mechanical characterization of age-related changes in the zebrafish vertebral column, Journal of the Mechanical Behavior of Biomedical Materials, 3, 84, pp54-63, (SCI)
2018 Chang SJ, Liao EC, Yeo HY, Kuo WH, Chen HY, Tsai YT, Wei YS, Chen YJ, Wang YS, Li JM, Shih CC, Chan CH, Lai ZY, Chou HC, Chuang YJ* and Chan HL*, Proteomic Investigating the Cooperative Lethal Effect of EGFR and MDM2 Inhibitors on Ovarian Carcinoma, Archives of Biochemistry and Biophysics, (SCI)
2018 Liu FY, Hsu TC, Choong P, Lin MH, Chuang YJ, Chen BS, Lin C., Uncovering the regeneration strategies of zebrafish organs: a comprehensive systems biology study on heart, cerebellum, fin, and retina regeneration., BMC systems biology, 12, Suppl 2, pp29-, (SCI)
2017 Tzu-Wei Wang, Kai-Chieh Chang,a Liang-Hsin Chen, Shih-Yung Liao,Chia-Wei Yeh and Yung-Jen Chuang, Effects of an injectable functionalized selfassembling nanopeptide hydrogel on angiogenesis and neurogenesis for regeneration of the central nervous system, Nanoscale, 9, pp16281-16292, (SCI)
2017 Bai YC, Hsia YC, Lin YT, Chen KH, Chou FI, Yang CM, Chuang YJ, Effect of tumor conditions on selective uptake of boric acid in human hepatoma HepG2 cells, Anticancer Research, (SCI)
2017 Chi-Hwa Yang, Yu-Jung Yeh, Jiz-Yuh Wang, Ya-Wen Liu, Yen-Lin Chen, Hui-Wen Cheng, Chun-Mei Cheng, Yung-Jen Chuang, Chiou-Hwa Yuh, and Yi-Rong Chen, NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish, Scientific Reports, (SCI)
2017 Wu HC, Lyau JB, Lin MS, Chuang YJ, Chen H , Multilayer Microfluidic Systems with Iridium-Tin-Oxide MicroelectrodMultilayer Microfluidic Systems with Iridium-Tin-Oxide Microelectrodes for Studying Biological Cells, Journal of Micromechanics and Microengineering, (SCI)
2017 Lai ZY, Yeo HY, Chen YT, Chang KM, Chen TC, Chuang YJ, Chang SJ., PI3K inhibitor enhances the cytotoxic response to etoposide and cisplatin in a newly established neuroendocrine cervical carcinoma cell line, Oncotarget, (SCI)
2017 Lee IJ, Yang YC, Hsu JW, Chang WT, Chuang YJ, Liau I, Zebrafish model of photochemical thrombosis for translational research and thrombolytic screening in vivo, Journal of Biophotonics, 4, pp494-502, (SCI)
2016 Liu LY, Lin MH, Lai ZY, Jiang JP, Huang YC, Jao LE, Chuang YJ, Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway, Journal of Biomedical Science, 23, 1, pp59-, (SCI)
2016 You MS, Jiang YJ, Yuh CH, Wang CM, Tang CH, Chuang YJ, Lin BH, Wu JL, Hwang SP, A Sketch of the Taiwan Zebrafish Core Facility, Zebrafish, Suppl 1, pp24-29, (SCI)
2016 Alice Ian Pan, Min-Hsuan Lin, Hui-Wen Chung, Hsin Chen, Shih-Rung Yeh, Yung-Jen Chuang, Yen-Chung Chang and Tri-Rung Yew , Direct-growth carbon nanotubes on 3D structural microelectrodes for electrophysiological recordings, Analyst, (SCI)
2015 Chen CJ, Tsai KC, Kuo PH, Chang PL, Wang WC, Chuang YJ, Chang MDT, A Heparan Sulfate-Binding Cell Penetrating Peptide for Tumor Targeting and Migration Inhibition, Biomed Research International., 2015, (SCI)
2014 Lin C, Lin CN, Wang YC, Liu FY, Chien YW, Chuang YJ, Lan CY, Hsieh WP, Chen BS, Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection, BMC Syst Biol., 8, S5, ppS6-, (SCI)
2014 Lin C, Lin CN, Wang YC, Liu FY, Chuang YJ, Lan CY, Hsieh WP, Chen BS, The role of TGF-ß signaling and apoptosis in innate and adaptive immunity in zebrafish: a systems biology approach, BMC Syst Biol., 8, 1, pp116-, (SCI)
2014 Lin LH, Chang SJ, Hu RY, Lin MW, Lin ST, Huang SH, Lyu PC, Chou HC, Lai ZY, Chuang YJ and Chan HL, Biomarker Discovery for Neuroendocrine Cervical Cancer, Electrophoresis, 35, 14, pp2039-2045, (SCI)
2014 Wang YC, Tsai IC, Lin C, Hsieh WP, Lan CY, Chuang YJ, Chen BS, Essential Functional Modules for Pathogenic and Defensive Mechanisms in Candida albicans Infections, Biomed Research International., 2014, 136130, (SCI)
2014 On the Crucial Cerebellar Wound Healing-Related Pathways and Their Cross-Talks after Traumatic Brain Injury in Danio rerio, PLoS One., 9, 6, ppe97902-, (SCI)
2013 Chen MH, Jan YH, Chang PM, Chuang YJ, Yeh YC, Lei HJ, Hsiao M, Huang SF, Huang CY, Chau GY, Expression of GOLM1 Correlates with Prognosis in Human Hepatocellular Carcinoma, Ann Surg Oncol. , Suppl 3, ppS616-624, (SCI)
2013 Chen CH, Ho YC, Ho HH, Chang IC, Kirsch KH, Chuang YJ, Layne MD, Yet SF, Cysteine-rich protein 2 alters p130Cas localization and inhibits vascular smooth muscle cell migration, Cardiovasc Res, 100, 3, pp461-471, (SCI)
2013 Lin CC, Chang TC, Lai CH, Chien CW, Liang CF, Adak AK, Chuang YJ, Chen YJ, Synthesis and Evaluation of a Photoactive Probe with a Multivalent Carbohydrate for Capturing Carbohydrate-Lectin Interactions, Bioconjug Chem, 24, 11, pp1895-1906, (SCI)
2013 11. Lai CH, Lai NC, Chuang YJ, Chou FI, Yang CM, Lin CC, Trivalent galactosyl-functionalized mesoporous silica nanoparticles as a target-specific delivery system for boron neutron capture therapy, Nanoscale, 5, 19, pp9412-9418, (SCI)
2013 Lai CH, Chang TC, Chuang YJ, Tzou DL, Lin CC, Stepwise Orthogonal Click Chemistry toward Fabrication of Paclitaxel/Galactose Functionalized Fluorescent Nanoparticles for HepG2 cell Targeting and Delivery, Bioconjug Chem, 24, 10, pp1698-1709, (SCI)
2013 Chen YY, Chao CC, Lui FC, Hsu PC, Chen HF, Peng CH, Chuang YJ, Hsieh WP, Wang DS., Dynamic transcript profiling of Candida albicans infection in zebrafish: a pathogen-host interaction study., PLoS One, 8, 9, ppe72483-, (SCI)
2013 Kuo ZY, Chuang YJ, Chao CC, Liu FC, Lan CY and Chen BS, Identification of infection-related and defense-related genes via a dynamic host-pathogen interaction network using a C. Albicans - zebrafish infection model, Journal of Innate Immunity, 5, 2, pp137-152, (SCI)
2013 Yeh CT, Su CL, Huang CY, Lin JK, Lee WH, Chang PM, Kuo YL, Liu YW, Wang LS, Wu CH, Shieh YS, Jan YH, Chuang YJ, Hsiao M, Wu AT, A preclinical evaluation of antimycin a as a potential antilung cancer stem cell agent, Evid Based Complement Alternat Med.
2013 12. Wang YC, Lin C, Chuang MT, Hsieh WP, Lan CY, Chuang YJ, Chen BS, Interspecies protein-protein interaction network construction for characterization of host-pathogen interactions: a Candida albicans-zebrafish interaction study., BMC Syst Biol., 7, 79, (SCI)
2013 Hsu PC, Chao CC, Yang CY, Ye YL, Liu FC, Chuang YJ, Lan CY, Diverse Hap43-independent functions of the Candida albicans CCAAT-binding complex, Eukaryot Cell., 12, 6, pp804-815, (SCI)
2013 Huang WC, Yang CC, Chen IH, Liu YM, Chang SJ, Chuang YJ, Treatment of Glucocorticoids Inhibited Early Immune Responses and Impaired Cardiac Repair in Adult Zebrafish, PLoS One, 8, 6, ppe66613-, (SCI)
2013 Chen IH, Wang HH, Hsieh YS, Yeh HI, Chuang YJ, PRSS23 is essential for the Snail-dependent endothelial to mesenchymal transition during valvulogenesis in zebrafish, Cardiovascular Research, 97, 3, pp443-453, (SCI)
2012 Yeh YT, Lee CI, Lim SH, Chen LJ, Wang WL, Chuang YJ, Chiu JJ, Convergence of physical and chemical signaling in the modulation of vascular smooth muscle cell cycle and proliferation by fibrillar collagen-regulated P66Shc, Biomaterials, 33, 28, pp6728-6738, (SCI)
2012 Jan YH, Tsai HY, Yang CJ, Huang MS, Yang YF, Lai TC, Lee CH, Jeng YM, Huang CY, Su JL, Chuang YJ, Hsiao M., Adenylate kinase 4 promotes lung cancer metastasis through the downregulation of ATF3 and correlates with poor clinical outcome, Cancer Res, 72, 19, pp5119-5129, (SCI)
2012 Chan HS, Chang SJ, Wang TY, Ko HJ, Lin YC, Lin KT, Chang KM, Chuang YJ, Serine protease PRSS23 is upregulated by estrogen receptor α and associated with proliferation of breast cancer cells, PLoS One, 7, 1, ppe30397-, (SCI)
2012 22. Chen FF, Lin WH, Lin SC, Kuo JH, Chu HY, Huang WC, Chuang YJ, Lee SC, Sue SC, Significance of heparin binding to basic residues in homologous to amino terminus domain of hepatoma-derived growth factor and related proteins, Glycobiology, 22, 5, pp649-661
2012 23. Lai CH, Lin YC, Chou FI, Liang CF, Lin EW, Chuang YJ, Lin CC., Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy., Chem Commun (Camb), 48, 4, pp612-614, (SCI)
2011 Chen BS, Lin YP, Chuang YJ, Robust H-infinity Observer-based Tracking Control of Stochastic Immune Systems under Environmental Disturbances and Measurement Noises, Asian J Control., 13, 5, pp667-690, (SCI)
2011 Peng CH, Liao CT, Peng SC, Chen YJ, Cheng AJ, Juang JL, Tsai CY, Chen TC, Chuang YJ, Tang CY, Hsieh WP, Yen TC, A novel molecular signature identified by systems genetics approach predicts prognosis in oral squamous cell carcinoma, PLoS One., 6, 8, ppe23452-, (SCI)
2011 Chen BS, Chang CH, Chuang YJ, Robust control of immune systems under noises: stochastic game approach, Springer Handbooks of Computational Statistics, (Others)
2011 Kuo MW, Wang CH, Wu HC, Chang SJ, Chuang YJ, Soluble THSD7A Is an N-Glycoprotein That Promotes Endothelial Cell Migration and Tube Formation in Angiogenesis, PLoS One, 6, 12, ppe29000-, (SCI)
2011 Wang CH, Chen IH, Kuo MW, Su PT, Lai ZY, Wang CH, Huang WC, Hoffman J, Kuo CJ, You MS, Chuang YJ, Zebrafish Thsd7a is a neural protein required for angiogenic patterning during development, Dev Dyn., 240, 6, pp1412-1421, (SCI)
2011 Luo WY, Shih YS, Lo WH, Chen HR, Wang SC, Wang CH, Chien CH, Chiang CS, Chuang YJ, Hu YC, Baculovirus vectors for antiangiogenesis-based cancer gene therapy, Cancer Gene Ther., (SCI)
2011 Lin, R.Z., Wang, T.P., Hung, R.J., Chuang, Y.J., Chien, C.C. and Chang, H.Y. , Tumor-induced Endothelial Cell Apoptosis: Roles of NAD(P)H Oxidase-Derived Reactive Oxygen Species, Journal of Cellular Physiolog, 226, 7, pp1750-1762, (SCI)
2011 Kang, C.C., Chuang, Y.J., Tung, K.C., Cho, C.C., Tang, C.Y., Peng, S.C. and Wong, D.S., A Genetic Algorithm-based Boolean Delay Model of Intracellular Signal Transduction in Inflammation, BMC Bioinformatics, 12, S1, ppS17-, (SCI)
2010 Yang, S.K., Wang, Y.C., Chao, C.C., Chuang, Y.J., Lan, C.Y. and Chen, B.S. , Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNF alpha-induced inflammatory responses, BMC Medical Genomics, 03, pp19-, (SCI)
2010 Wang, C.H., Su, P.T., Du, X.Y., Kuo, M.W., Lin, C.Y., Yang, C.C., Chan, H.S., Chang, S.J., Kuo, C., Seo, K., Leung, L.L. and Chuang, Y.J., Thrombospondin Type I Domain Containing 7A (THSD7A) Mediates Endothelial Cell Migration and Tube Formation, Journal of Cellular Physiology, 222, 3, pp685-694, (SCI)
2010 Peng, S.C., Wong, D.S.H., Tung, K.C., Chen, Y.Y., Chao, C.C., Peng, C.H., Chuang, Y.J.* and Tang, C.Y. , Computing modeling with forward and reverse engineering links signaling network and genomic regulatory responses: NF-kappa B signaling-induced gene expression responses in inflammation, BMC Bioinformatics , 11, pp308-, (SCI)
2010 Lai, C.H., Lin, C.Y., Wu, H.T., Chan, H.S., Chuang, Y.J., Chen, C.T. and Lin, C.C. , Galactose Encapsulated Multifunctional Nanoparticle for HepG2 Cell Internalization, Advanced Functional Materials, 20, 22, pp3948-3958, (SCI)
2010 Huang, W.C., Hsieh, Y.S., Chen, I.H., Wang, C.H., Chang, H.W., Yang, C.C., Ku, T.H., Yeh, S.R. and Chuang, Y.J., Combined Use of MS-222 (Tricaine) and Isoflurane Extends Anesthesia Time and Minimizes Cardiac Rhythm Side Effects in Adult Zebrafish, Zebrafish, 7, 3, pp297-304, (SCI)
2010 Chao, C.C., Hsu, P.C., Jen, C.F., Chen, I.H., Wang, C.H., Chan, H.C., Tsai, P.W., Tung, K.C., Wang, C.H., Lan, C.Y., Chuang, Y.J., Zebrafish as a Model Host for Candida albicans Infection, Infection and Immunity , 78, 6, pp2512-2521, (SCI)
2009 Chen, G.Y., Shiah, H.C., Su, H.J., Chen, C.Y., Chuang, Y.J., Lo, W.H., Huang, J.L., Chuang, C.K., Hwang, S.M. and Hu, Y.C. , Baculovirus Transduction of Mesenchymal Stem Cells Triggers the Toll-Like Receptor 3 Pathway, Journal of Virology, 83, 20, pp10548-10556, (SCI)
2008 Chen, M.L., Adak, A.K., Yeh, N.C., Yang, W.B., Chuang, Y.J., Wong, C.H., Hwang, K.C., Hwu, J.R.R., Hsieh, S.L. and Lin, C.C. , Fabrication of an Oriented Fc-Fused Lectin Microarray through Boronate Formation, Angewandte Chemie-International Edition, 47, 45, pp8627-8630, (SCI)
2008 Chen, B.S., Yang, S.K., Lan, C.Y. and Chuang, Y.J., A systems biology approach to construct the gene regulatory network of systemic inflammation via microarray and databases mining, BMC Medical Genomics , 1, pp46-, (SCI)
2008 Chen, B.S., Chang, C.H. and Chuang, Y.J., Robust model matching control of immune systems under environmental disturbances: Dynamic game approach, Journal of Theoretical Biology , 253, 4, pp824-837, (SCI)
2006 Zhang, W.Q., Chuang, Y.J., Jin, T.Q., Swanson, R., Xiong, Y., Leung, L. and Olson, S.T., Antiangiogenic antithrombin induces global changes in the gene expression profile of endothelial cells, Cancer Research , 66, 10, pp5047-5055, (SCI)
发表日期 专利名称 专利国别 着作人
2017/02/01 具细胞亲和力与电容耦合性之立体电极及包含其之生物探针 中华民国 庄永仁 / 潘怡安、游萃蓉、陈新、庄永仁
2014/12/01 Devices and methods for tracking moving objects (美国专利) 美国 庄永仁 / 黄诗音,陈永昌,庄永仁
2014/11/01 追踪移动物件之装置与方法 (中华民国专利) 中华民国 庄永仁 / 黄诗音,陈永昌,庄永仁
2014/04/01 Transparent zebrafish and preparation method thereof (美国专利) USA 庄永仁 / 庄永仁,黄威彰
国家 学校名称 系所 学位 期间
美国 伊利诺大学芝加哥分校 生物工程系 博士 1994.09 ~ 2000.06
中华民国 国立清华大学 化学工程系 学士 1985.09 ~ 1989.06
服务机关名称 单位 职务 期间
国立清华大学 医学科学系 系主任 2014.08 ~ 2016.08
国立清华大学 秘书处校友服务中心 主任 2014.02 ~ 2014.07
国立清华大学 医学科学系 暨 生物资讯与结构生物研究所 教授 2013.08 ~ 迄今
国立清华大学 医学科学系 暨 生物资讯与结构生物研究所 副教授 2010.08 ~ 2013.07
国立清华大学 生命科学系 暨 生物资讯与结构生物研究所 助理教授 2004.08 ~ 2010.07
美国 史丹福大学 医学系 血液科 博士后研究员 2000.09 ~ 2004.05
类别 年度 奖项名称 颁奖单位
校内荣誉 2014 杰出教学奖 国立清华大学
校内荣誉 2011 教师教学绩优奖 国立清华大学生命科学院
校内荣誉 2010 教师教学绩优奖 国立清华大学生命科学院
校内荣誉 2007 杰出教学奖 国立清华大学